An alternative is to take pregnancy safe mefloquine instead since the usual combo of chloroquine plus proguanil cannot be used.
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in 2003 a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor tlr 9 family receptors.
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impact of the revised american academy of ophthalmology guidelines regarding hydroxychloroquine screening on actual practice.
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chloroquine hydroxychloroquine us aralen organs and systems cardiovascular electrocardiographic changes, comprising altered t waves and prolongation of the qt interval, are not uncommon during high-dose treatment with chloroquine.
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the relative risk of hospital admission or early termination of travel possibly related to prophylaxis was higher with mefloquine than with either chloroquine or chloroquine plus proguanil; the relative risks 95 ci were 162, 612, and 261 respectively.
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as with chloroquine, antacids may reduce absorption of hydroxychloroquine so it is advised that a 4 hour interval be observed between plaquenil and antacid dosaging.
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