Pregnancy and breast-feeding methotrexate may cause birth defects and fetal and newborn death if you take it while you are pregnant.

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methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.

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simeprevir minor systemic exposure of methotrexate, a substrate of the drug transporter breast cancer resistance protein bcrp , may be increased when administered concurrently with simeprevir, a bcrp inhibitor.

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certainly, if the patient has rheumatoid arthritis and is taking other medications, such as methotrexate, periodic lab tests would be done anyway, but nothing beyond what you would use in your ordinary practice with those patients.

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the time for methotrexate to leave the body also varies with dose.

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