Deaths have been reported with the use of methotrexate in the treatment of malignancy, psoriasis, and rheumatoid arthritis.

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there are two literature reports roenigk, 1969 and nyfors, 1978 describing large series n 204, 248 of psoriasis patients treated with methotrexate.

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early work using a five-drug regimen comprising vincristine, methotrexate, cyclophosphamide, prednisolone and 5-fluorouracil suggested that very high response rates could be obtained, but greater experience showed that the response rate was nearer 50 .

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there are various theories of how methotrexate specifically inhibits rheumatoid inflammatory activity.

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