A study of data from 2,000 women who took zofran among 600,000 births in denmark from 2004-2011 found no significant increased risk of birth defects.

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separately, a 2006 study looked at the effects of zofran on children who visited a pediatric emergency department with gastroenteritis a viral infection that can cause diarrhea and vomiting and dehydration.

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interestingly, half of the babies were exposed to zofran after the first trimester, when they were no longer at risk of major birth defects.

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in 2011 the national center for biotechnology information released a study that showed a direct link between zofran and birth defects.

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