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Metabolism and EliminationPropranolol is extensively metabolized with most metabolites appearing in the urinePropranolol is metabolized through 3 primary routesAromatic hydroxylationmainly 4-hydroxylationN-dealkylation followed by further side-chain oxidationand direct glucuronidationIt has been estimated that the percentage contributions of these routes to total metabolism are 4241and 17respectivelybut with considerable variability between individualsThe 4 major metabolites are propranolol glucuronidenaphthyloxylactic acidand glucuronic acid and sulfate conjugates of 4-hydroxy propranolol.
For regularshort-actingInnoPran XLTake the missed dose as soon as you rememberSkip the missed dose if your next dose is less than 4 hours away.
Impact of Propranolol on Other Drugs WarfarinWarfarin concentrations are increased when administered with propranololMonitor prothrombin time accordinglysee Clinical Pharmacology12.7
This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.
Hemangeol must be given to an infant during or just after a feedingDoses should be spaced at least 9 hours apartMake sure your child gets fed regularly while taking this medicineTell your doctor when the child has any changes in weightHemangeol doses are based on weight in childrenand any changes may affect your child’s dose.
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