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According to results from the first clinical trial to systematically investigate the optimal administration of methotrexate in patients with active rheumatoid arthritis, published in the january 2008 issue of arthritis rheumatism, methotrexate injection also referred to as subcutaneous methotrexate is significantly more effective than oral administration of methotrexate at the same dosage, with no increase in side effects.

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Do not take this medicine with any of the following medications -cisapride -droperidol -terfenadine -tizanidine this medicine may also interact with the following medications -antacids -birth control pills -caffeine -cyclosporin -didanosine ddi buffered tablets or powder -medicines for diabetes -medicines for inflammation like ibuprofen, naproxen -methotrexate -multivitamins -omeprazole -phenytoin -probenecid -sucralfate -theophylline -warfarin.

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Rheumatoid arthritis the usual adult dose of methotrexate is 7.

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