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the mechanism of action of bupropion appears involve a unique, not well-understood, noradrenergic neurotransmission.
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a study by papakostas and associates examined the impact of bupropion vs ssris on sleepiness and fatigue in patients with depression.
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these symptoms happened more often in people who had a history of mental health problems before taking bupropion than in people without a history of mental health problems.
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following a single dose in humans, peak plasma concentrations of hydroxybupropion occur approximately 3 hours after administration of wellbutrin tablets.
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