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C and d, representative confocal images showing nuclear translocation of p65 green in cells collected from the peritoneal cavity of mice subjected to a single dose or chronic minocycline treatment.
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To attenuate the inflammatory response, minocycline disrupts signaling of t cells to activate the microglia, which in turn reduces proinflammatory cytokine biomarkers such as nf-kappa b, inf-alpha, il-1b, etc.
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