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Precose significantly reduces after-meal glucose levels.
Information about Precose.
Because its mechanism of action is differentthe effect of Precose to enhance glycemic control is additive to that of sulfonylureasinsulin or metformin when used in combinationIn additionPrecose diminishes the insulinotropic and weight-increasing effects of sulfonylureas.
Symptoms of high blood sugarhyperglycemiainclude thirstincreased urinationconfusiondrowsinessflushingrapid breathingand fruity breath odorIf these symptoms occurtell your doctor right awayYour dosage may need to be increased or you may need other drugs.
There have been rare postmarketing reports of pneumatosis cystoides intestinalis associated with the use of alpha-glucosidase inhibitorsincluding PrecosePneumatosis cystoides intestinalis may present with symptoms of diarrheamucus dischargerectal bleedingand constipationComplications may include pneumoperitoneumvolvulusintestinal obstructionintussusceptionintestinal hemorrhageand intestinal perforationIf pneumatosis cystoides intestinalis is suspecteddiscontinue Precose and perform the appropriate diagnostic imaging.
The recommended starting dosage of PRECOSE is 25 mg given orally three times daily at the startwith the first biteof each main mealHoweversome patients may benefit from more gradual dose titration to minimize gastrointestinal side effectsThis may be achieved by initiating treatment at 25 mg once per day and subsequently increasing the frequency of administration to achieve 25 mg t.i.d.
In contrast to sulfonylureasPrecose does not enhance insulin secretionThe antihyperglycemic action of acarbose results from a competitivereversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymesPancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestinewhile the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharidestrisaccharidesand disaccharides to glucose and other monosaccharides in the brush border of the small intestineIn diabetic patientsthis enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia.
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some drugs that are taken on the side of the medication of precose can interact to give some good and some bad effects.
