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Closer monitoring of patients with hypothyroidism co-administered with sevelamer hydrochloride and levothyroxine is recommended (see section 4.5).
The active ingredient in Renagel Tablets is sevelamer hydrochloride.a polymeric amine that binds phosphate and is meant for oral administration. Sevelamer hydrochloride is poly(allylamine hydrochloride) crosslinked with epichlorohydrin in which forty percent of the amines are protonated. It is known chemically as poly(allylamine-co-N.’-diallyl-1.-diamino2-hydroxypropane) hydrochloride. Sevelamer hydrochloride is hydrophilic.but insoluble in water. The structure is represented in Figure 1.
In peritoneal dialysis.there has been one study comparing Renagel with calcium acetate in 143 patients over 12 weeks.
May decrease serum levels of fat soluble vitamins and folic acid in pregnant women. consider supplementation.
No Renagel treatment-related effects on labor and delivery were seen in animal studies. The effects of Renagel on labor and delivery in humans purchase renagel phosphate not known [see Nonclinical Toxicology (13.1)] .
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