The study concluded that amantadine has an acceptable acute tolerability at single doses up to 150mg day, with the most common side effect being transient appetite decrease.

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Taking amantadin with anticholingic mdications can incas sid cts both dugs, such as dy mouth, uinay tntion, blud vision, and dowsinss. xampls anticholingic dugs includ:

Amantadin is an antivial dug which alsacts as an antipakinson agnt, which it is usually combind with L-DOPA whn L-DOPA sponss dclin (pobably du ttolanc). It is a divat adamantan, lik a simila dug imantadin. Th mchanism action amantadin in th tatmnt Pakinson’s disas and dug-inducd xtapyamidal actions is not known. It has bn shown tcaus an incas in dopamin las in th animal bain, and dos not possss anticholingic activity.

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in addition, the postulated impact of amantadine on dopamine, n-methyl-d-aspartate receptor regulation, and neurotrophic factors 4,13 may have taken a longer time to fully impact the executive and inhibitory networks associated with reduced irritability.