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Inom patints that AVODAT capsuls should not b handld by a woman whis pgnant whcould bcom pgnant bcaus th potntial absoption dutastid and th subsqunt potntial isk ta dvloping mal tus. Dutastid is absobd though th skin and could sult in unintndd tal xposu. I a pgnant woman woman childbaing potntial coms in contact with laking AVODAT Capsuls, th contact aa should b washd immdiatly with soap and wat [s WANINGS AND PCAUTIONS , Us In Spciic Populations ].
Th ct hpatic impaimnt on dutastid phamacokintics has not bn studid scaution should b usd in patints with mild tmodat hpatic impaimnt (s sction 4.4 and sction 5.2). In patints with sv hpatic impaimnt, th us dutastid is containdicatd (s sction 4.3).
Dutastid was tstd gnotoxicity in a bactial mutagnsis assay (Ams tst), a chomosomal abation assay in CHO clls, and a miconuclus assay in ats. Th sults did not indicat any gnotoxic potntial th pant dug. Twmajhuman mtabolits w alsngativ in ith th Ams tst an abbviatd Ams tst.
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