The co-administration of medications known as proton pump inhibitors such as omeprazole prilosec , lansoprazole prevacid , esomeprazole nexium , pantoprazole protonix , and rabeprazole aciphex , and a medication that provides back protective prostaglandins called misoprostol cytotec can also decrease gastrointestinal bleeding associated with these medications.

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If you are taking this drug to prevent stomach ulcerstake it by mouth usually four times a dayafter meals and at bedtime to minimize diarrheaor as directed by your doctor.

Blood/Coagulationanemiaabnormal differentialthrombocytopeniapurpuraESR increased.

Avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after you have stopped treatmentIf you become pregnant while taking misoprostolcontact your doctor right away.

The risk of uterine rupture associated with misoprostol use in pregnancy increases with advancing gestational ages and prior uterine surgeryincluding Cesarean deliveryGrand multiparity also appears to be a risk factor for uterine rupture.

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cytotec is usually taken with meals and at bedtime.