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Transmucosal Route Clotrimazole oral lozenges are used for local treatment and are not significantly bioavailableConcentrations persisting in saliva are believed to be due to clotrimazole binding to oral mucosa.
Clotrimazole inhibits the movement of calcium and potassium ions across the cell membraneThis action may be responsible for in vitro and animal data demonstrating an antitumor effect of clotrimazoleThis action may also explain why clotrimazole prevents the dehydration of the red blood cell in patients with sickle cell diseaseClotrimazole inhibits the loss of intracellular potassium by blocking the ion transport pathway known as the Gardos channel.
Confirm diagnosis by KOH smear and/or culturesIf ineffectivereconfirm diagnosis before repeating therapyPregnancyCat.B
Concomitant use of condomsdiaphragmsor tamponsnot recommendedConfirm diagnosis by KOH smear and/or culturesIf ineffectivereconfirm diagnosis before repeating therapyPregnancyCat.B
Clotrimazole should be used with caution in patients with azole antifungals hypersensitivityHypersensitivity reactions may be due to the various vehicles present in the different clotrimazole formulationsClotrimazole may have a cross sensitivity with other azole derivatives.
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