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Reversible transaminase elevationsASTALThave been observed following corticosteroid therapyThese changes have generally been small and not associated with any clinical syndromeToxic hepatitis has been reported with high doses of cyclically pulsed IV therapyonset has been several weeks or longerResolution has been reported with discontinuationhoweverrecurrence has been reported with rechallengeRef]
1Product InformationSolu-MedrolmethylPREDNISolone sodium succinatePfizer U.SPharmaceuticals GroupNew YorkNY.
Potentiated by CYP3A4 inhibitorsegketoconazolemacrolidescyclosporineestrogensAntagonized by CYP3A4 inducersegbarbituratesphenytoincarbamazepinerifampincholestyramineMay potentiate cyclosporineseizure riskMay antagonize oral anticoagulantsmonitorisoniazidIncreased risk of arrhythmias with digitalisMay need to adjust dose of antidiabetic agentsMonitor for hypokalemia with potassium-depleting drugsegamphotericin BdiureticsConcomitant neuromuscular blocking agentsincreased risk of myopathyWithdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapyAminoglutethimide may lead to loss of corticosteroid-induced adrenal suppressionIncreased GI effects with aspirinother NSAIDsCaution with aspirin in hypoprothrombinemiaMay suppress reactions to skin tests.
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