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Granulocytopenia is commonly associated with zidovudineThereforepatients who receive nevirapine and zidovudine concomitantly and especially paediatric patients and patients who receive higher zidovudine doses or patients with poor bone marrow reservein particular those with advanced HIV diseasehave an increased risk of granulocytopeniaIn such patients haematological parameters should be carefully monitored.
Because virus resistant to all available NNRTIs can be selected rapidly during failure of a nevirapine-containing regimenit is important to assess patient motivation and discuss possible side effects and strategies for their management before treatment with nevirapine is initiated.
HematologyAnemiaeosinophilianeutropenia Investigationsdecreased serum phosphorus.
NevirapineCo-administration of ritonavir does not lead to any clinically relevant change in nevirapine plasma levels.
For patients less than 3 years and for all other age groupsan immediate-release oral suspension dosage form is availableplease refer to the respective Summary of Product Characteristics
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