The probability of experiencing 1 a significant suicide attempt, including a completed suicide, or 2 hospitalization because of imminent suicide risk, including increased level of surveillance for suicidality for patients already hospitalized, was lower for clozapine tablets patients than for olanzapine patients at week 104 clozapine tablets 24 versus olanzapine 32 ; 95 ci of the difference 2 , 14 figure 1 .

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Use caution in patients at risk of pneumoniamay cause esophageal dysmotility and aspiration.

Drug Reaction with Eosinophilia and Systemic SymptomsDRESSreported with olanzapine exposureDRESS may present with a cutaneous reactionsuch as rash or exfoliative dermatitiseosinophiliafeverand/or lymphadenopathy with systemic complications such as hepatitisnephritispneumonitismyocarditisand/or pericarditisDRESS is sometimes fataldiscontinue olanzapine if DRESS suspected.

There may be an increased risk of elevated blood sugar levels and diabetes with olanzapine as well as the other antipsychotic medications in its classPatients should be tested during treatment for elevated blood sugarAdditionallypersons with risk factors for diabetesincluding obesity or a family history of diabetesshould have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetesAny patient developing symptoms that suggest diabetes during treatment should be tested for diabetes.

Very stiffrigidmuscleshigh fevertremorssweatingconfusionfast or uneven heartbeatsslow heart ratefeeling like you might pass outtwitching or uncontrollable movements of your eyeslipstonguefacearmsor legstrouble speaking or swallowingdry mouththirstfeeling very hotwith or without sweatingurinating less than usual or not at allhigh blood sugarincreased thirstloss of appetitefruity breath odorincreased urinationdrowsinessdry skinnauseaand vomitingsudden numbness or weaknessconfusionor problems with visionspeechor balancefeverchillsbody achesflu symptomssores in your mouth and throatswelling in your hands or feetchanges in personalityunusual thoughts or behaviorhallucinationsor thoughts about hurting yourselfor upper stomach painitchingloss of appetitedark urineclay-colored stoolsjaundiceyellowing of the skin or eyes

This document does not contain all possible interactionsThereforebefore using this producttell your doctor or pharmacist of all the products you useKeep a list of all your medications with youand share the list with your doctor and pharmacistCheck with your physician if you have health questions or concerns.

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hepatic impairment — although the presence of hepatic impairment may be expected to reduce the clearance of olanzapine, a study of the effect of impaired liver function in subjects n 6 with clinically significant childs pugh classification a and b cirrhosis revealed little effect on the pharmacokinetics of olanzapine.