This section reports additional, less frequent adverse events which occurred among the patients taking clozaril in clinical trials.

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If myocarditis or cardiomyopathy are suspectedClozaril treatment should be promptly stopped and the patient immediately referred to a cardiologistsee section 4.4

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

An approximately 3-fold increased risk of cerebrovascular adverse events has been seen in randomised placebo controlled clinical trials in the dementia population with some atypical antipsychoticsThe mechanism for this increased risk is not knownAn increased risk cannot be excluded for other antipsychotics or other patient populationsClozapine should be used with caution in patients with risk factors for stroke.

Owing to its anti-alpha-adrenergic propertiesClozaril may reduce the blood-pressure-increasing effect of norepinephrine or other predominantly alpha-adrenergic agents and reverse the pressor effect of epinephrine.

While clozapine can provide great benefitsit can rarely cause seriouspossibly fatal side effectsFor this reasonclozapine is used when other treatments have not worked or you cannot take them.

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