Venlafaxine might also enhance the anti-blood-clotting effect of such blood thinners as warfarin coumadin, jantoven , as well as aspirin, and non-steroidal anti-inflammatory drugs nsaids , including ibuprofen advil, motrin .

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Information about Coumadin.

If you’re planning to get pregnanttalk with your doctor about the problems you could have and what you can do to have a baby safely.

Your risk of having bleeding problems is higher than the possible benefit of treatmentYour healthcare provider will decide if COUMADIN is right for youyou are pregnant unless you have a mechanical heart valveCOUMADIN may cause birth defectsmiscarriageor death of your unborn babyyou are allergic to warfarin or any of the other ingredients in COUMADINSee the end of this leaflet for a complete lis t of ingredients in COUMADIN.

Hemorrhagic tendencies or blood dyscrasias Recent or contemplated surgery of the central nervous system or eyeor traumatic surgery resulting in large open surfacessee WARNINGS AND PRECAUTIONSBleeding tendencies associated withActive ulceration or overt bleeding of the gastrointestinalgenitourinaryor respiratory tract Central nervous system hemorrhage Cerebral aneurysmsdissecting aorta Pericarditis and pericardial effusions Bacterial endocarditis Threatened abortioneclampsiaand preeclampsia Unsupervised patients with conditions associated with potential high level of non-compliance Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding Hypersensitivity to warfarin or to any other components of this producte.ganaphylaxissee ADVERSE REACTIONSMajor regional or lumbar block anesthesia Malignanthypertension.

CYP2C9 and VKORC1 genotype informationwhen availablecan assist in selection of the initial dose of warfarinsee DOSAGE AND ADMINISTRATION

Coumadinwarfarinis an anticoagulantblood thinnerWarfarin reduces the formation of blood clots.

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this means that if a major bleeding episode does occur, the potential for a bad outcome may be higher than with coumadin.