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Inhibition of prostaglandin synthesis might adversely affect pregnancyData from epidemiological studies suggest an increased risk of spontaneous abortion after use of prostaglandin synthesis inhibitors in early pregnancyIn animalsadministration of prostaglandin synthesis inhibitors has been shown to result in increased preand post-implantation lossNSAIDs should not be used during the first two trimesters of pregnancy or labour unless the potential benefit to the patient outweighs the potential risk to the foetus.

If the patient has developed SJS or TEN with the use of piroxicampiroxicam must not be re-started in this patient at any time.

Cardiac glycosidesNSAIDs may exacerbate cardiac failurereduce GFR and increase plasma glycoside levels.

A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polypsseverepotentially fatal bronchospasmand/or intolerance to aspirin and other NSAIDsBecause cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patientsFELDENE is contraindicated in patients with this form of aspirin sensitivitysee CONTRAINDICATIONSWhen FELDENE is used in patients with preexisting asthmawithout known aspirin sensitivitymonitor patients for changes in the signs and symptoms of asthma.

Do not use any other over-the-counter coldallergyor pain medication without first asking your doctor or pharmacistMany medicines available over the counter contain aspirin or other medicines similar to piroxicamsuch as ibuprofenketoprofenor naproxenIf you take certain products together you may accidentally take too much of this type of medicationRead the label of any other medicine you are using to see if it contains aspirinibuprofenketoprofenor naproxen.

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