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Other Adverse Reactions Observed During The Premarketing And Postmarketing Clinical Trial Evaluation Of CYMBALTA In Adults.

Changes in sexual desiresexual performance and sexual satisfaction often occur as manifestations of psychiatric disorders or diabetesbut they may also be a consequence of pharmacologic treatmentBecause adverse sexual reactions are presumed to be voluntarily underreportedthe Arizona Sexual Experience ScaleASEXa validated measure designed to identify sexual side effectswas used prospectively in 4 MDD placebo-controlled trialsIn these trialsas shown in Table 5 belowpatients treated with CYMBALTA experienced significantly more sexual dysfunctionas measured by the total score on the ASEXthan did patients treated with placeboGender analysis showed that this difference occurred only in malesMales treated with CYMBALTA experienced more difficulty with ability to reach orgasmASEX Item 4than males treated with placeboFemales did not experience more sexual dysfunction on CYMBALTA than on placebo as measured by ASEX total scoreNegative numbers signify an improvement from a baseline level of dysfunctionwhich is commonly seen in depressed patientsPhysicians should routinely inquire about possible sexual side effects.

Take Cymbalta exactly as prescribed by your doctorFollow all directions on your prescription labelDo not take this medicine in larger or smaller amounts or for longer than recommended.

Antidepressants increased the risk of suicidal thoughts and behavior in childrenadolescentsand young adults in short-term studies.

The most commonly observed adverse reactions in CYMBALTA-treated patientsas defined abovewere nauseasomnolencedecreased appetiteconstipationhyperhidrosisand dry mouth.

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