Goserelin lowers plasma oestrogen 1 ; fulvestrant prevents receptor dimerization and activation 2 ; tamoxifen binds to the active complex, inactivating its role in initiating transcription 3 .

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Information about Tamoxifen.

Tamoxifen is the generic form of the brand-name drug Soltamoxwhich is used to treat some types of breast cancer in men and women.

To make sure you can safely take tamoxifentell your doctor if you have any of these conditionsLiver disease High cholesterol or triglyceridesa type of fat in the bloodA history of stroke or blood clot A history of cataract If you are receiving chemotherapy or radiation.

Even if your periods have stopped or are irregularyou still need to use contraceptionYour doctor or nurse can tell you more about this.

ATamoxifen blocks the actions of estrogena female hormonein the bodySome types of breast cancer cells require estrogen to growThis type of breast cancer is calledestrogen-dependentTamoxifen is used to treat and prevent this type of breast cancerAccording to the prescribing information for tamoxifeninsomnia occurred in approximately 9of patients participating in clinical trials of the medicationNo other sleep disturbances were describedOther common side effects of tamoxifen include hot flasheswarmth under the skinbone or tumor painskin changesswelling in the hands or feetvaginal itching or drynessdepressionweaknessweight lossnauseadecreased sex drive or difficulty having an orgasmheadachedizzinessand thinning hairThis is not a complete list of side effects that can occur with tamoxifenFor more specific informationconsult with your doctor or local pharmacist for guidance based on your health status and current medicationsSarah LewisRPh.

These are common and are often mildbut this can varyHot flushes and sweats may lessen after the first few monthsSome people continue to have them for as long as they take tamoxifen.

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john s wort -red yeast rice this medicine may also interact with the following medications -acetaminophen -agents that lower cholesterol -alcohol -allopurinol -amiodarone -antibiotics or medicines for treating bacterial, fungal or viral infections -azathioprine -barbiturate medicines for inducing sleep or treating seizures -certain medicines for diabetes -certain medicines for heart rhythm problems -certain medicines for high blood pressure -chloral hydrate -cisapride -disulfiram -female hormones, including contraceptive or birth control pills -general anesthetics -herbal or dietary products like garlic, ginkgo, ginseng, green tea, or kava kava -influenza virus vaccine -male hormones -medicines for mental depression or psychosis -medicines for some types of cancer -medicines for stomach problems -methylphenidate -nsaids, medicines for pain and inflammation, like ibuprofen or naproxen -propoxyphene -quinidine, quinine -raloxifene -seizure or epilepsy medicine like carbamazepine, phenytoin, and valproic acid -steroids like cortisone and prednisone -tamoxifen -thyroid medicine -tramadol -vitamin c, vitamin e, and vitamin k -zafirlukast -zileuton.