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Imuran is usually given as a single daily dose on the day of, and in a minority of cases 1 to 3 days before, transplantation.
Information about Imuran.
Benefit versus risk must be weighed carefully before use of IMURAN in patients of reproductive potentialThere are no adequate and well-controlled studies in pregnant womenIf this drug is used during pregnancy or if the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard to the fetusWomen of childbearing age should be advised to avoid becoming pregnant.
Take a missed dose as soon as you think about itIf it is close to the time for your next doseskip the missed dose and go back to your normal timeDo not take 2 doses at the same time or extra doses.
IMURAN is indicated for the treatment of active rheumatoid arthritisRAto reduce signs and symptomsAspirinnon-steroidal anti-inflammatory drugs and/or low dose glucocorticoids may be continued during treatment with IMURANThe combined use of IMURAN with disease modifying anti-rheumatic drugsDMARDshas not been studied for either added benefit or unexpected adverse effectsThe use of IMURAN with these agents cannot be recommended.
The mechanisms whereby azathioprine affects autoimmune diseases are not knownAzathioprine is immunosuppressivedelayed hypersensitivity and cellular cytotoxicity tests being suppressed to a greater degree than are antibody responsesIn the rat model of adjuvant arthritisazathioprine has been shown to inhibit the lymph node hyperplasiawhich precedes the onset of the signs of the diseaseBoth the immunosuppressive and therapeutic effects in animal models are dose-relatedAzathioprine is considered a slow-acting drug and effects may persist after the drug has been discontinued.
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