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Although estrogen-containing oral contraceptives have been shown to increase the clearance of lamotriginesee CLINICAL PHARMACOLOGYno adjustments to the recommended dose-escalation guidelines for LAMICTAL should be necessary solely based on the use of estrogen-containing oral contraceptivesThereforedose escalation should follow the recommended guidelines for initiating adjunctive therapy with LAMICTAL based on the concomitant AED or other concomitant medicationssee Table 1 or Table 5See below for adjustments to maintenance doses of LAMICTAL in women taking estrogen-containing oral contraceptives.

Get emergency medical help if you have any of these signs of an allergic reactionhivesfeverswollen glandspainful sores in or around your eyes or mouthdifficulty breathingswelling of your facelipstongueor throat.

Taking the anticonvulsant and mood stabilizing drugs valproic acid or divalproex sodium along with Lamictal can double the amount of Lamictal that stays in your bodyThis effect can greatly increase your chances of side effects from Lamictal.

The more common side effects of Lamictal in people treated for bipolar I disorder include:

Patientstheir caregiversand families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of the signs and symptoms of depressionany unusual changes in mood or behaviorthe emergence of suicidal thoughts or suicidal behavioror thoughts about self-harmBehaviors of concern should be reported immediately to healthcare providers.

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