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CUse with caution if benefits outweigh risksAnimal studies show risk and human studies not available or neither animal nor human studies done.
When Cytoxan is included in combined cytotoxic regimensit may be necessary to reduce the dose of Cytoxan as well as that of the other drugs.
To reduce the likelihood of adverse reactions that appear to be administration rate-dependente.gfacial swellingheadachenasal congestionscalp burningcyclophosphamide should be injected or infused very slowlyDuration of the infusion also should be appropriate for the volume and type of carrier fluid to be infused.
Handle and dispose of cyclophosphamide in a manner consistent with other cytotoxic drugs1 Caution should be exercised when handling and preparing Cyclophosphamide for InjectionUSPlyophilized powderor bottles containing cyclophosphamide tabletsTo minimize the risk of dermal exposurealways wear gloves when handling vials containing Cyclophosphamide for InjectionUSPlyophilized powderor bottles containing cyclophosphamide tabletsThe coating of the cyclophosphamide tablets prevents direct contact of persons handling the tablets with the active substanceHoweverto prevent inadvertent exposure to the active substancethe cyclophosphamide tablets should not be cutchewedor crushedPersonnel should avoid exposure to broken tabletsIf contact with broken tablets occurswash hands immediately and thoroughly.
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