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It is recommended that liver enzyme tests be performed before the initiation of CRESTOR and if signs or symptoms of liver injury occurAll patients treated with CRESTOR should be advised to promptly report any symptoms that may indicate liver injuryincluding fatigueanorexiaright upper abdominal discomfortdark urine or jaundice.
There have been rare postmarketing reports of cognitive impairmente.gmemory lossforgetfulnessamnesiamemory impairmentconfusionassociated with statin useThese cognitive issues have been reported for all statinsThe reports are generally nonseriousand reversible upon statin discontinuationwith variable times to symptom onset1 day to yearsand symptom resolutionmedian of 3 weeks
Patients should be advised to report promptly unexplained muscle paintendernessor weaknessparticularly if accompanied by malaise or fever or if these muscle signs or symptoms persist after discontinuing CRESTOR.
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