Plasma concentrations, half-life, and clearance of olanzapine may vary between individuals on the basis of smoking status, gender, and age see dosage and administration and clinical pharmacology .
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osimertinib major monitor electrolytes and ecgs for qt prolongation if coadministration of olanzapine with osimertinib is necessary; an interruption of osimertinib therapy and dose reduction may be necessary if qt prolongation occurs.
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new born infants exposed to antipsychotics including olanzapine during the third trimester of pregnancy are at risk of adverse reactions including extrapyramidal and or withdrawal symptoms that may vary in severity and duration following delivery.
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in five placebo controlled studies of olanzapine in elderly patients with dementia related psychosis n 1184 , the following treatment emergent adverse events were reported in olanzapine treated patients at an incidence of at least 2 and significantly greater than placebo treated patients falls, somnolence, peripheral edema, abnormal gait, urinary incontinence, lethargy, increased weight, asthenia, pyrexia, pneumonia, dry mouth and visual hallucinations.
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