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The principal effect of metoclopramide is on symptoms of postprandial and daytime heartburn with less observed effect on nocturnal symptomsIf symptoms are confined to particular situationssuch as following the evening mealuse of metoclopramide as single doses prior to the provocative situation should be consideredrather than using the drug throughout the dayHealing of esophageal ulcers and erosions has been endoscopically demonstrated at the end of a 12-week trial using doses of 15 mg q.i.dAs there is no documented correlation between symptoms and healing of esophageal lesionspatients with documented lesions should be monitored endoscopically.

Metoclopramide is contraindicated in patients with known sensitivity or intolerance to the drugMetoclopramide should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactionssince the frequency and severity of seizures or extrapyramidal reactions may be increased.

The principal effect of metoclopramide is on symptoms of postprandial and daytime heartburn with less observed effect on nocturnal symptomsIf symptoms are confined to particular situationssuch as following the evening mealuse of metoclopramide as single doses prior to the provocative situation should be consideredrather than using the drug throughout the dayHealing of esophageal ulcers and erosions has been endoscopically demonstrated at the end of a 12-week trial using doses of 15 mg q.i.dAs there is no documented correlation between symptoms and healing of esophageal lesionspatients with documented lesions should be monitored endoscopically.

Metoclopramide increases the tone and amplitude of gastricespecially antralcontractionsrelaxes the pyloric sphincter and the duodenal bulband increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transitIt increases the resting tone of the lower esophageal sphincterIt has littleif anyeffect on the motility of the colon or gallbladder.

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you must also avoid certain medications that may interact with reglan to cause side effects.