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The relative beta 1 -selectivity of metoprolol diminishes and blockade of beta 2 -adrenoceptors increases at plasma concentration above 300 nmol l. read more →
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2018
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In five controlled studies in normal healthy subjects, the same daily doses of toprol-xl and immediate-release metoprolol were compared in terms of the extent and duration of beta 1 – blockade produced. read more →
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Apr
2018
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Cyp2d6 inhibitors drugs that inhibit cyp2d6 such as quinidine, fluoxetine, paroxetine, and propafenone are likely to increase metoprolol concentration see clinical pharmacology 12. read more →
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Apr
2018
