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AThe most frequently reported side effects of acyclovirZoviraxfor oral administrationdiffered in clinical trials depending on the indication for useDuring clinical trials of treatment of genital herpeswith short-term administration of acyclovirthe most frequently reported adverse reactions included nausea and/or vomitingDuring clinical trials of treatment with long-term administration with acyclovir for genital herpesthere were two methods of administration evaluatedIn trials evaluating continuous administration to prevent recurrencesthe most frequently reported adverse reactions included nausea and diarrhea and in those evaluating intermittent treatment of recurrences over one year diarrheanausea and headache were reportedThe most frequently reported adverse reaction during clinical trials of shingles was malaiseLastlyduring clinical trials of treatment of chickenpox with acyclovirthe most frequently reported adverse reaction was diarrheaMore serious side effects of acyclovir are possible with treatmentKidney failurein some cases causing deathhas been reported with acyclovir treatmentPatients are advised to maintain adequate hydration and drink plenty of water while taking acyclovir to keep the kidneys working properlyThere is also a warning regarding thrombotic thrombocytopenic purpura/hemolytic uremic syndromeTTP/HUSwhich has occurred in immunocompromised patients administered acyclovirPatients should be advised to contact their health care provider immediately if they experience symptoms which may indicate the occurrence of more serious side effects of acyclovirSymptoms may include pain the lower backurinating less than usual or not urinating at alleasy bruising or bleedingand unusual weaknessPatients are instructed to consult with their health care provider if they experience any other unusualsevere or troublesome side effects while being treated with acyclovir.

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Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.

This means within three days of a shingles rash and within 24 hours of a chicken pox rash.

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