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They are not at increased risk for developing clozaril-induced neutropenia.

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except for bone marrow suppression during initial clozaril clozapine therapy, there are no other established risk factors, based on worldwide experience, for the development of agranulocytosis in association with clozaril clozapine use.

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commonly cast-off second-generation atypical antipsychotic drugs include aripiprazole abilify , clozapine clozaril , olanzapine zyprexa , quetiapine seroquel , quetiapine fumarate seroquel xr , risperidone risperdal , long-acting risperidone risperdal consta , ziprasidone geodon , and paliperidone invega .

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clozaril concentrations may be increased in these patients, because clozaril is almost completely metabolized and then excreted.

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however, if the inducer is necessary, it may be necessary to increase the clozaril dose.

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since its introduction in 1990, clozaril has helped over 225,000 people with schizophrenia.


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