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Use the lowest effective dosage for the shortest possible duration. Avoid administration of more than one NSAID at a time. Avoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleeding. For such patients.as well as those with active GI bleeding.consider alternate therapies other than NSAIDs. Remain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapy. If a serious GI adverse event is suspected.promptly initiate evaluation and treatment.and discontinue MOBIC until a serious GI adverse event is ruled out. In the setting of concomitant use of low-dose aspirin for cardiac prophylaxis.monitor patients more closely for evidence of GI bleeding [see DRUG INTERACTIONS ].

The mechanism of action of MOBIC.like that of other NSAIDs.is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Mobic can increase your risk of fatal heart attack or stroke.especially if you use it long term or take high doses.or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft.or CABG).

Because clinical trials are conducted under widely varying conditions.adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical mobic over the counter of another drug and may not reflect the rates observed in practice.

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