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Chloroquine will be escalated in 3 dose-levels 200mg, 400mg and 600mg up each containing a minimum of 3 and a maximum of 6 patients.

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7. Goldstein JH “Effects of drugs on cornea.conjunctiva.and lids.” Int Ophthalmol Clin 11 (1971). 13-34.

It is very important to continue taking this medication exactly as prescribed by your doctor. Do not take more or less of this drug than prescribed. Do not stop taking it before completing treatment.even if you feel better.unless directed to do so by your doctor. Skipping or changing your dose without approval from your doctor may cause prevention/treatment to be ineffective.cause the amount of parasite to increase.make the infection more difficult to treat (resistant).or worsen side effects.

Order chloroquine diphosphate with history of epilepsy should be advised about the risk of chloroquine provoking seizures.

A. Preparation of NHS-Carrier Substances. A carrier substance with available hydroxyl groups such as carbohydrates (i.e. CD.or inulin).PEG and other grafted polymers described herein.is derivatized to provide an NHS ester. In a suitable anhydrous solvent such as DMF.the carrier substance is coupled to acetic anhydride and purified as described herein.to provide carboxyl groups. Then.the carboxylic acid group is reacted with N-hydroxysuccinimide and an aromatic carbodiimide such as N.N-dicyclohexyl carbodiimide.at approximately equimolar ratios and reacted at rt for 1-3 Hrs. The product.N-hydroxysuccinimide carrier (i.e. NHS-PEG).is separated in the filtrate from precipitated dicyclohexylurea.collected by evaporation and purified by chromatography.

In patients with preexisting auditory damage.chloroquine should be administered with caution. In case of any defects in hearing.chloroquine should be immediately discontinued.and the patient closely observed (see ADVERSE REACTIONS ).

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