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Falciparum have become resistant to 4-aminoquinoline compounds including chloroquine and hydroxychloroquine .
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Cdc has published recommendations for malaria chemoprophylaxis for travelers to affected areas of east africa 2 ; fansidar sulfadoxine 500 mg plus pyrimethamine 25 mg one tablet weekly plus chloroquine 300 mg base once weekly is currently recommended.
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Crtf another gene involved is chloroquine resistance transporter factor crtf .
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usage of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgement of the physician the benefit outweighs the potential risk to the fetus.
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