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While used for the short-term treatment of acute exacerbations of chronic inflammatory bowel disease such as ulcerative colitis and crohn s disease, prednisolone should not be used in patients where there is a possibility of impending gi perforation, abscess, or pyogenic infection.

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aprepitant, when administered as a 3-day oral regimen 125 mg 80 mg 80 mg , is a moderate cyp3a4 inhibitor and inducer and may increase plasma concentrations of prednisolone.

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