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An acute myopathy has been observed with the use of high doses of corticosteroids.most often occurring in patients with disorders of neuromuscular transmission (e.g..myasthenia gravis).or in patients receiving concomitant therapy with neuromuscular blocking drugs (e.g..pancuronium). This acute myopathy is generalized.may involve ocular and respiratory muscles.and may result in quadriparesis. Elevation of creatinine kinase may occur. Clinical improvement or recovery after stopping corticosteroids may require weeks to years.

Rare instances of anaphylactoid reactions have occurred in patients receiving corticosteroid therapy (see ADVERSE REACTIONS ).

Hepatic side effects are frequently experienced following oral administration of Decadron.as injectable preparations bypass hepatic circulation and are not subject to regulation by the liver. There have been reports of Hepatomegaly (enlarged liver).and rarely hepatitis of the liver.

Using aspirin or similar pain medication while taking dexamethasone may increase your risk of gastrointestinal effects. Ask your doctor about whether you can take both together.

Use with caution in cirrhosis.diverticulitis.myasthenia gravis.peptic ulcer disease.ulcerative colitis.renal insufficiency.pregnancy.

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